Today, children and young people are global citizens, powerful agents of change, and the next generation of caregivers, scientists, and doctors. Any crisis presents the opportunity to help them learn, cultivate compassion and increase resilience while building a safer and more caring community. Having information and facts about COVID-19 will help diminish students’ fears and anxieties around the disease and support their ability to cope with any secondary impacts in their lives. This guide provides key messages and considerations for engaging school administrators, teachers and staff, parents, caregivers, and community members, as well as children themselves in promoting safe and healthy schools.